celiac disease

Celiac Disease

  • Systemic autoimmune disease triggered by dietary gluten peptides found in wheat, rye, barley, and related grains.
  • Common, affecting up to 1% of the general population, and may present at any age.
  • Presentation is varied and ranges from diarrhoea and failure to thrive, to iron-deficiency anaemia or osteoporosis.
  • Diagnosis is suggested by positive immunoglobulin A tissue transglutaminase serology, but must be confirmed by duodenal biopsy and histology.
  • The only current therapy is a strict, lifelong gluten-free diet.
  • Complications of untreated coeliac disease include gastrointestinal symptoms, malabsorption, increased risk of malignancy, and higher overall mortality than in the general population